Jan 22nd, 2024
Pre-con: Stroke in the Lab World
Independent, unbiased and streamlined multicenter preclinical trial platforms are needed, with impartial funding, centralized blinding, randomization, independent data analysis, accountability and quality control.
Cenk Ayata
Moderated by Cenk Ayata, MD, PhD, the Feb. 6 Stroke in the Lab World pre-conference sessions will include:
- NINDS Priorities for Translation in Stroke
- Innovations in Addressing the Translational Knowledge Gap
- Discovery vs. Confirmatory Testing
- Selecting the Best Candidates for Confirmative Preclinical Studies
- Should We Mimic Clinical Trials? Do We Need a New Design for Preclinical Trials
- Which/How Many Stroke Models/ Species to Employ
- Comorbidities in Multicenter Preclinical Trials
- Standardization vs. Heterogeneity? What to Control for?
- Statistical Models
After lunch, sessions will include:
- Clinical Correlation vs. Species-specific Readouts?
- Neurological Readouts: Which Tests?
- Tissue Readouts: From Histology to Imaging
- Artificial Intelligence in Outcome Assessments
- How to Handle Mortality as an Outcome and a Confounder
- Infrastructure Challenges: Randomization, Blinding, Tracking, Data Storage, Analysis
- Harmonization of Outcome Readouts Across a Network
- Common Data Elements
- Medium, Format and Principles for Sharing the Outcomes With the Community
A separate registration is required to attend this Pre-Conference Symposia.
